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Paper
Paper
Editorial
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Vincenzo Naddeo and Haizhou Liu present an ‘Editorial Perspective’ on coronavirus in wastewater and discuss the water research needs to combat viral outbreaks.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 27 Mar 2020
Environ. Sci.: Water Res. Technol., 2020, Advance Article
https://doi.org/10.1039/D0EW90015J
Environ. Sci.: Water Res. Technol., 2020, Advance Article
https://doi.org/10.1039/D0EW90015J
Perspective
Trends and targets in antiviral phototherapy
With its principles discovered more than a hundred years ago the photodynamic inactivation of viruses is now routinely employed in the decontamination of blood products but also investigated for HPV treatment and water disinfection and food safety.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 09 Aug 2019
Photochem. Photobiol. Sci., 2019,18, 2565-2612
https://doi.org/10.1039/C9PP00211A
Photochem. Photobiol. Sci., 2019,18, 2565-2612
https://doi.org/10.1039/C9PP00211A
Minireview
Novel biosensing methodologies for ultrasensitive detection of viruses
Biosensors function as rapid, sensitive and specific diagnostic tools for various viral infectious diseases.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 23 Aug 2013
Analyst, 2013,138, 6219-6229
https://doi.org/10.1039/C3AN01394D
Analyst, 2013,138, 6219-6229
https://doi.org/10.1039/C3AN01394D
Application
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Recent developments in the biological activities of polyoxometalates (metal-oxide cluster anions) are discussed from the chemotherapeutic point of view for a novel inorganic drug.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 21 Jul 2005
J. Mater. Chem., 2005,15, 4773-4782
https://doi.org/10.1039/B504585A
J. Mater. Chem., 2005,15, 4773-4782
https://doi.org/10.1039/B504585A
Review Article
Antiviral drug discovery: broad-spectrum drugs from nature
Exploiting the power of nature to fight viral infections. This review describes the concept of direct- and host-acting natural products with broad-spectrum antiviral activities and provides promising examples derived from plants, fungi, bacteria and marine organisms.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 15 Oct 2014
Nat. Prod. Rep., 2015,32, 29-48
https://doi.org/10.1039/C4NP00085D
Nat. Prod. Rep., 2015,32, 29-48
https://doi.org/10.1039/C4NP00085D
Critical Review
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
This review provides a comprehensive look at whether a pandemic enveloped virus would pose challenges for the wastewater and drinking water industries.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 03 Jul 2015
Environ. Sci.: Water Res. Technol., 2015,1, 735-746
https://doi.org/10.1039/C5EW00125K
Environ. Sci.: Water Res. Technol., 2015,1, 735-746
https://doi.org/10.1039/C5EW00125K
Critical Review
The role of biosensors in the detection of emerging infectious diseases
An ideal approach to real-time disease detection and surveillance.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 11 Jul 2006
Analyst, 2006,131, 1079-1090
https://doi.org/10.1039/B603402K
Analyst, 2006,131, 1079-1090
https://doi.org/10.1039/B603402K
Communication
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The continued emergence and spread of infectious agents is of great concern, and systems biology approaches to infectious disease research can advance our understanding of host–pathogen relationships and facilitate the development of new therapies and vaccines.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 10 Jan 2017
Analyst, 2017,142, 442-448
https://doi.org/10.1039/C6AN02486F
Analyst, 2017,142, 442-448
https://doi.org/10.1039/C6AN02486F
Communication
Inhibition of SARS coronavirus helicase by bismuth complexes
The SARS-CoV NTPase/helicase being able to unwind both RNA and DNA duplexes, is an attractive target for anti-viral drug design. A series of bismuth complexes were synthesized and characterized, and exhibit the inhibition against the SARS helicase ATPase and duplex-unwinding activities at micromolar concentrations.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 16 Aug 2007
Chem. Commun., 2007, 4413-4415
https://doi.org/10.1039/B709515E
Chem. Commun., 2007, 4413-4415
https://doi.org/10.1039/B709515E
Paper
Rapid detection of multiple respiratory viruses based on microfluidic isothermal amplification and a real-time colorimetric method
We developed a real-time colorimetric method based on LAMP-integrated microfluidic chip system for diagnosing multiple respiratory viruses.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 15 Oct 2018
Lab Chip, 2018,18, 3507-3515
https://doi.org/10.1039/C8LC00841H
Lab Chip, 2018,18, 3507-3515
https://doi.org/10.1039/C8LC00841H
Paper
Synthesis and antiviral activity of novel spirocyclic nucleosides
A diverse range of spirocyclic nucleosides have been prepared from a common precursor and tested for their antiviral activity.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 17 Oct 2018
New J. Chem., 2018,42, 18363-18380
https://doi.org/10.1039/C8NJ02777C
New J. Chem., 2018,42, 18363-18380
https://doi.org/10.1039/C8NJ02777C
PaperHigh-resolution lipidomics reveals dysregulation of lipid metabolism in respiratory syncytial virus pneumonia mice
Respiratory syncytial virus (RSV) is a leading viral pathogen responsible for lower respiratory tract infections, particularly in children under five years worldwide, often resulting in hospitalization.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 17 Aug 2018
RSC Adv., 2018,8, 29368-29377
https://doi.org/10.1039/C8RA05640D
RSC Adv., 2018,8, 29368-29377
https://doi.org/10.1039/C8RA05640D
Paper
![Graphical abstract: Different positions of amide side chains on the benzimidazo[1,2-a]quinoline skeleton strongly influence biological activity](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C8NJ00416A&imageInfo.ImageIdentifier.Year=2018 "C8NJ00416A")
Different positions of amide side chains on the benzimidazo[1,2-a]quinoline skeleton strongly influence biological activity
Benzimidazo[1,2-a]quinolines substituted with amide chains have been evaluated for their antiproliferative, antibacterial and antiviral activity in vitro.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 23 Mar 2018
New J. Chem., 2018,42, 7096-7104
https://doi.org/10.1039/C8NJ00416A
New J. Chem., 2018,42, 7096-7104
https://doi.org/10.1039/C8NJ00416A
PaperSelf-assembled star-shaped chiroplasmonic gold nanoparticles for an ultrasensitive chiro-immunosensor for viruses
Nanoengineered chiral gold nanoparticles and quantum dots for ultrasensitive chiroptical sensing of viruses in blood samples.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 22 Aug 2017
RSC Adv., 2017,7, 40849-40857
https://doi.org/10.1039/C7RA07175B
RSC Adv., 2017,7, 40849-40857
https://doi.org/10.1039/C7RA07175B
Paper
High sensitive and direct fluorescence detection of single viral DNA sequences by integration of double strand probes onto microgels particles
A novel class of probes for fluorescence detection was developed and combined to microgel particles for a high sensitive fluorescence detection of nucleic acids.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 22 Dec 2015
Analyst, 2016,141, 1250-1256
https://doi.org/10.1039/C5AN02001H
Analyst, 2016,141, 1250-1256
https://doi.org/10.1039/C5AN02001H
Paper
Curcumin modified silver nanoparticles for highly efficient inhibition of respiratory syncytial virus infection
Uniform and stable curcumin-AgNPs, which are synthesized with a simple method, show excellent antiviral properties against respiratory syncytial virus.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 06 Jan 2016
Nanoscale, 2016,8, 3040-3048
https://doi.org/10.1039/C5NR07918G
Nanoscale, 2016,8, 3040-3048
https://doi.org/10.1039/C5NR07918G
PaperLabDisk with complete reagent prestorage for sample-to-answer nucleic acid based detection of respiratory pathogens verified with influenza A H3N2 virus
Sample supply remains the only manual handling step for pathogen detection at the point-of-care.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 26 Nov 2015
Lab Chip, 2016,16, 199-207
https://doi.org/10.1039/C5LC00871A
Lab Chip, 2016,16, 199-207
https://doi.org/10.1039/C5LC00871A
Paper
Structure-based virtual screening and experimental validation of the discovery of inhibitors targeted towards the human coronavirus nucleocapsid protein
Nucleocapsid protein (NP), an essential RNA-binding viral protein in human coronavirus (CoV)-infected cells, is an antiviral target for drug discovery.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 20 Oct 2015
Mol. BioSyst., 2016,12, 59-66
https://doi.org/10.1039/C5MB00582E
Mol. BioSyst., 2016,12, 59-66
https://doi.org/10.1039/C5MB00582E
Paper
Continuous aerosol size separator using inertial microfluidics and its application to airborne bacteria and viruses
A novel microchannel-based inertial separator that can rapidly and continuously separate submicron aerosols according to particle inertial differences and Dean vortices in the airflow was developed.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 16 Feb 2015
Lab Chip, 2015,15, 1889-1897
https://doi.org/10.1039/C5LC00079C
Lab Chip, 2015,15, 1889-1897
https://doi.org/10.1039/C5LC00079C
Paper
Approaches to design non-covalent inhibitors for human granzyme B (hGrB)
A structure-based design campaign for non-covalent small molecule inhibitors of hGrB was carried out by virtual screening employing three constraints and probe site-mapping with FTMAP to identify ligand “hot spots”.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 23 Sep 2014
Org. Biomol. Chem., 2014,12, 8952-8965
https://doi.org/10.1039/C4OB01874E
Org. Biomol. Chem., 2014,12, 8952-8965
https://doi.org/10.1039/C4OB01874E
Paper
Rapid identification of H5 avian influenza virus in chicken throat swab specimens using microfluidic real-time RT-PCR
Microfluidic PCR system with an integrated online fluorescence detection module and an embedded computer for real-time data processing.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 17 Jan 2014
Anal. Methods, 2014,6, 2628-2632
https://doi.org/10.1039/C3AY42126K
Anal. Methods, 2014,6, 2628-2632
https://doi.org/10.1039/C3AY42126K
Paper
Under-three minute PCR: Probing the limits of fast amplification
SARS was chosen due to its importance as a public health threat and exemplar of the potential benefits of ultra-fast PCR in rapid screening.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 27 Jul 2011
Analyst, 2011,136, 3707-3712
https://doi.org/10.1039/C1AN15365J
Analyst, 2011,136, 3707-3712
https://doi.org/10.1039/C1AN15365J
Paper
Rapid detection for primary screening of influenza A virus: microfluidic RT-PCR chip and electrochemical DNA sensor
We demonstrate the use of a continuous-flow polydimethylsiloxane (PDMS) microfluidic RT-PCR chip and disposable electrical printed (DEP) chips for rapid amplification and sensing of new influenza (AH1pdm) virus of swine-origin.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 25 Mar 2011
Analyst, 2011,136, 2064-2068
https://doi.org/10.1039/C1AN15066A
Analyst, 2011,136, 2064-2068
https://doi.org/10.1039/C1AN15066A
Paper
A self-contained all-in-one cartridge for
A self-contained all-in-one cartridge for sample preparation and real-time PCR in rapid influenza diagnosis
This work demonstrates a fully automated system with multiplexing capability for the rapid diagnosis of infectious diseases. The system automatically performs DNA/RNA sample preparation, reagent metering, aliquot dispensing, and real-time RT-PCR with self-contained reagents in a disposable polymer cartridge.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 24 Sep 2010
Lab Chip, 2010,10, 3103-3111
https://doi.org/10.1039/C005265E
Lab Chip, 2010,10, 3103-3111
https://doi.org/10.1039/C005265E
Paper
RNA aptamer-based sensitive detection of SARS coronavirus nucleocapsid
RNA aptamer-based sensitive detection of SARS coronavirus nucleocapsid protein
We describe the high-affinity RNA aptamers capable of capturing SARS coronavirus (SARS-CoV) nucleocapsid (N) protein. A nanoarray aptamer chip with the selected aptamer might have application potential for rapid, sensitive detection of SARS coronavirus.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 21 Jul 2009
Analyst, 2009,134, 1896-1901
https://doi.org/10.1039/B906788D
Analyst, 2009,134, 1896-1901
https://doi.org/10.1039/B906788D
Paper
An optimized method to detect influenza virus and human rhinovirus from exhaled breath and the airborne environment
Patricia Fabian, James Joseph McDevitt, Wai-Ming Lee, Eugene Andres Houseman and Donald Kirby Milton
Virus detection was improved 10-fold, by using the optimal molecular biology methods to extract nucleic acid (RNA), reverse transcribe RNA and quantify cDNA using quantitative PCR.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 01 Dec 2008
J. Environ. Monit., 2009,11, 314-317
https://doi.org/10.1039/B813520G
J. Environ. Monit., 2009,11, 314-317
https://doi.org/10.1039/B813520G
Paper
Molecular design of
Molecular design of inhibitors against the Mproprotein of the severe acute respiratory syndrome (SARS) virus
The main proteinase of SARS coronavirus (3CLpro or Mpro) is crucial for its replication process, and therefore it is a potential target for the development of anti-SARS drugs.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 08 Nov 2007
New J. Chem., 2008,32, 452-458
https://doi.org/10.1039/B704880G
New J. Chem., 2008,32, 452-458
https://doi.org/10.1039/B704880G
Paper
Development of a method for bacteria and virus recovery from heating, ventilation, and air conditioning (HVAC) filters
To determine prevalence of natural background pathogens and pathogens’ near neighbors in ambient air, high volume bioaerosol sampling could be conducted using preexisting HVAC filters in building air handling units.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 06 Sep 2006
J. Environ. Monit., 2006,8, 1006-1013
https://doi.org/10.1039/B606132J
J. Environ. Monit., 2006,8, 1006-1013
https://doi.org/10.1039/B606132J
Paper
Screening of specific
Screening of specific antigens for SARS clinical diagnosis using a protein microarray
An antigen screening method based on protein microarray is developed and applied to the screening of SARS-CoV antigens. The most specific antigen (N2) screened out is demonstrated by ELISA assay.
From the themed collection: Coronavirus articles - free to access collection
The article was first published on 14 Feb 2005
Analyst, 2005,130, 474-482
https://doi.org/10.1039/B415888A
Analyst, 2005,130, 474-482
https://doi.org/10.1039/B415888A
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